Purpose: To present a 1-year-old boy with cyclic neutropenia who presented with multiple episodes of Periorbital cellulitis (POC). Methods: The child presented with three episodes of POC. In the second episode, the cellulitis was associated with nasolacrimal duct obstruction, and in the third episode, a pansinusitis was noted. He underwent a thorough systemic evaluation. Results: Patient’ s evaluation revealed the diagnosis of cyclic neutropenia. Conclusion: This report emphasizes the possibility of an underlying immunodeficiency with recurrent POC, even in an apparently healthy child.

Purpose: Among the three forms of anthrax in human (cutaneous, inhalational, and gastrointestinal), cutaneous anthrax is the most common form with prevalence of 95%. The cutaneous anthrax is a rare cause of Periorbital (preseptal) cellulitis that may remained without correct diagnosis and appropriate treatment. This may result in severe local complications such as blindness and airway obstruction or dissemination of the disease like as bacteremia and meningitis.Objective: We report a child with Periorbital anthrax to present the clinical manifestation and progression of the disease and remind physicians the interesting contagious cause of Periorbital cellulitis.Case report: A 2.5-year-old boy from a rural area of Guilan province in Iran was seen to have a small erythematous papule in his right lower eyelid 5 days prior to admission. Then, the lesion progressed to a necrotic ulcer with a black central scar and severe surrounding edema and erythema. Severe swelling of the eyelids and edema all over the face occurred as well. Fever was absent. The child had repetitious contacts with domestic herbivores. The CT scan of the orbit and paranasal sinuses showed soft tissue swelling only. Gram-positive rods were seen in the smear of exudate taken from cutaneous lesion but culture result showed negative. Treatment with intravenous ciprofloxacin, penicillin, and clindamycin resulted in clinical improvement but due to cicatricial ectropion formation, oculoplastic intervention was considered to be done.Conclusion: Physicians must consider a cutaneous lesion to be anthrax if any of the following exists: a history of contact with domestic herbivores and animals, similar lesions in the family members, cutaneous necrotic ulcer with the characteristic black scar and peripheral edema, and observing gram-positive rods in scraped material taken from beneath the scar edge or exudate of cutaneous lesions. Although anthrax of the eyelids is not common, it must be included in the differential diagnosis of Periorbital cellulitis.

Introduction: Among the three human forms of anthrax (cutaneous, inhalational, and gastrointestinal), the cutaneous form is the most common disease (95%). Cutaneous anthrax is a rare cause of Periorbital (preseptal) cellulitis, therefore, diagnosis and initiation of treatment may be delayed. On the other hand, without correct diagnosis and appropriate treatment, Periorbital anthrax may result in sever local complications such as blindness and airway obstruction, or dissemination of the disease like bacteremia and meningitis. In this research was introduced a child with Periorbital anthrax to present the clinical manifestation and progression of the disease and remind physicians to interest contagious cause of Periorbital cellulitis.Case Report: A 2.5 years old boy from a rural area of Guilan who was suffered of a small erythematous papule in his right lower eyelid 5 days prior to admission. Then, the lesion progressed to a necrotic ulcer with a black central eschar, edema and erythema at the area around. Sever swelling of eyelids and edema occurred all over the face. Fever wasn’t observed. The child had repetitious contacts with domestic herbivores. CT scan of the orbit and paranasal sinuses showed soft tissue swelling only. Gram-positive rods were seen in the smear of exudate taken from cutaneous lesion but culture result showed negative. Treatment with intravenous ciprofloxacin, penicillin, and clindamycin resulted in clinical improvement but due to cicatricial ectropion formation, oculoplastic intervention was considered to be done.Conclusion: Physicians must consider it to be anthrax if any of the following symbols exists: a history of contact with domestic herbivores and animals, similar lesions in the family members, cutaneous necrotic ulcer with the characteristic black eschar and edema of the area around, and observing Gram-positive rods in scraped material taken from beneath the eschar edge or exudate of cutaneous lesions. Although anthrax of the eyelids is not common disease, it must be consider as in the differential diagnosis of Periorbital cellulitis.

Purpose: Osteomyelitis of the orbital bones presenting as an orbital cellulitis is a rare form of extrapulmonary tuberculosis (TB). We report a rare case of tubercular osteomyelitis of the orbital bones presenting as a Periorbital cellulitis. Case Report: A seven-year-old female child presented to our tertiary eye care center with swelling involving the right eyelids and the right cheek for two months. She had been provisionally diagnosed elsewhere as pre-septal cellulitis and had been given oral antibiotics. We clinically diagnosed her as orbital cellulitis, but her non-responsiveness to intravenous antibiotics prompted us to get a contrast enhanced computed tomography (CECT) of the orbit and paranasal sinuses, which was suggestive of tubercular etiology. However, the patient had no foci for TB elsewhere. We used a relatively new, but rapid test, called Cartridge-based Nucleic Acid Amplification Test (CBNAAT) on the pus aspirate which was positive for TB. Thereafter, the patient was started on anti-tubercular treatment to which she responded wonderfully. Conclusion: A high index of suspicion should be kept for TB infection in cases of orbital cellulitis with unusual clinical behavior in an endemic region such as India.

Purpose: To report a case of acute myelogenous leukemia (AML) presenting with Periorbital cellulitis and progressing to facial and neck cellulitis. Case Report: A 17 year old male patient presented with Periorbital cellulitis which progressed to the right hemifacial and neck area. He did not respond to regular antibiotic therapy. Peripheral blood smear showed leukocytosis with predominance of immature cells, thrombocytopenia and anemia. Bone marrow biopsy confirmed a diagnosis of acute myelogenous leukemia.Conclusion: Acute leukemia must be considered in the differential diagnosis of Periorbital cellulitis.

We presented a middle-aged woman with nonspecific signs and symptoms, including dyspnea, lower limb edema, and elevated jugular venous pressure. Among these, the skin changes including nail changes, macroglossia and Periorbital rash were the most important clues to suspect primary amyloidosis. Paraclinical studies were anemia, proteinuria and restricted cardiomyopathy. Abdominal fat pad biopsy is usually the first step to confirm the amyloidosis. However, despite the negative histologic result of fat-pad biopsy, we performed duodenal biopsy that confirmed amyloidosis. This case report demonstrates the important value of duodenal tissue in order to conform the diagnosis of amyloidosis.

Introduction: Periorbital tuberculosis is rare and usually associated with involvement of other organs. Most of these patients have underlying cause.Diagnosis is difficult and depends on microbiologic and histological study. Case report: A 17 years old student referred to Shahid Mohammadi Hospital with Periorbital mass since 12 weeks ago with impression of bacterial periobital abscess. Incision and drainage was done and the patient received 7 days Iv Antibiotic therapy and was discharged with relative improvement. The patient referred again with recurrence of the symptoms. Culture of drained puss in special media showed mycobacterium Tuberculosis. The patient received 6 months antituberculous therapy with improvement, No recurrence is seen in 12 months follow up.Conclusion: We must consider Periorbital tuberculosis in patients with refractory Periorbital infection without tuberculosis involvement of other organs.